Molecular characterization of EGFR and EGFRvIII signaling networks in human glioblastoma tumor xenografts.

@article{Johnson2012MolecularCO,
  title={Molecular characterization of EGFR and EGFRvIII signaling networks in human glioblastoma tumor xenografts.},
  author={Hannah Johnson and Amanda M Del Rosario and Bryan D. Bryson and Mark A Schroeder and Jann N. Sarkaria and Forest M. White},
  journal={Molecular & cellular proteomics : MCP},
  year={2012},
  volume={11 12},
  pages={1724-40}
}
Glioblastoma multiforme (GBM) is a malignant primary brain tumor with a mean survival of 15 months with the current standard of care. Genetic profiling efforts have identified the amplification, overexpression, and mutation of the wild-type (wt) epidermal growth factor receptor tyrosine kinase (EGFR) in ≈ 50% of GBM patients. The genetic aberration of wtEGFR is frequently accompanied by the overexpression of a mutant EGFR known as EGFR variant III (EGFRvIII, de2-7EGFR, ΔEGFR), which is… CONTINUE READING