Molecular characterization of Cyclophilin (TcCyP19) in Trypanosoma cruzi populations susceptible and resistant to benznidazole.

  title={Molecular characterization of Cyclophilin (TcCyP19) in Trypanosoma cruzi populations susceptible and resistant to benznidazole.},
  author={J. V. R{\^e}go and A. Duarte and D. Liarte and Francirlene de Carvalho Sousa and H. M. Barreto and J. Bua and A. Romanha and G. R{\'a}dis-Baptista and S. Murta},
  journal={Experimental parasitology},
  • J. V. Rêgo, A. Duarte, +6 authors S. Murta
  • Published 2015
  • Biology, Medicine
  • Experimental parasitology
  • Cyclophilin (CyP), a peptidyl-prolyl cis/trans isomerase, is a key molecule with diverse biological functions that include roles in molecular chaperoning, stress response, immune modulation, and signal transduction. In this respect, CyP could serve as a potential drug target in disease-causing parasites. Previous studies employing proteomics techniques have shown that the TcCyP19 isoform was more abundant in a benznidazole (BZ)-resistant Trypanosoma cruzi population than in its susceptible… CONTINUE READING
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