Molecular characterization and regulation of the angiotensin-converting enzyme type 2/Angiotensin-(1-7)/MAS receptor axis during the ovulation process in cattle

@article{TonellottodosSantos2012MolecularCA,
  title={Molecular characterization and regulation of the angiotensin-converting enzyme type 2/Angiotensin-(1-7)/MAS receptor axis during the ovulation process in cattle},
  author={Joabel Tonellotto dos Santos and Rog{\'e}rio Ferreira and Bernardo Garziera Gasperin and Lucas Carvalho Siqueira and Jo{\~a}o Francisco Coelho de Oliveira and Robson A. S. Santos and Adelina M Reis and Paulo Bayard Gonçalves},
  journal={Journal of the Renin-Angiotensin-Aldosterone System},
  year={2012},
  volume={13},
  pages={91 - 98}
}
The objective of this study was to characterize the profiles of Ang-(1-7), MAS receptor, ACE2, NEP and PEP during the ovulatory process in cattle. For this study, 40 synchronized cows with follicular diameter ≥ 12 mm were ovariectomized at different time-points (0, 3, 6, 12 and 24 h) after i.m. application of gonadotropin-releasing hormone (GnRH) to induce a luteinizing hormone surge. Follicular fluid was collected for measuring Ang-(1-7) by radioimmunoassay. Theca and granulosa cells were… Expand
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References

SHOWING 1-10 OF 36 REFERENCES
Angiotensin-(1-7), its receptor Mas, and the angiotensin-converting enzyme type 2 are expressed in the human ovary.
TLDR
Angiotensin-(1-7), its receptor Mas, and ACE2 are expressed in the human ovary, and the peptide is present in several ovarian compartments and can be quantified in FF. Expand
Angiotensin-(1-7): a novel peptide in the ovary.
TLDR
The higher level of Ang-(1-7) in proestrus and estrus as well as in eCG-treated rats suggests the involvement of this renin-Ang system peptide in pre- and postovulatory events. Expand
Gonadotropin Stimulation Increases the Expression of Angiotensin-(1–7) and Mas Receptor in the Rat Ovary
TLDR
Gonadotropin-induced changes in the ovarian expression of Ang-(1—7), Mas receptor, and ACE2 are shown to suggest that the renin-angiotensin system (RAS) branch formed by ACE2/Ang-(1-7)/Mas, fully expressed in the rat ovary and regulated by gonadotropic hormones, could play a role in the ovary physiology. Expand
Localized accumulation of angiotensin II and production of angiotensin-(1-7) in rat luteal cells and effects on steroidogenesis.
TLDR
The data suggest that steroidogenesis may be modulated by angiotensin peptides that act in part through intracellular AT1 receptors. Expand
Cyclooxygenase-2 and its role in ovulation: a 2004 account.
TLDR
A comprehensive review of the events that led to the characterization of COx-2 in pre-ovulatory follicles is presented, current concepts on the control of COX-2 expression inPre-ovulation follicles are updated, and the consequences of CO X-2 inhibition to women fertility and potential implications ofCOX- 2 expression in ovarian cancer are addressed. Expand
Gonadotropin-induced expression of messenger ribonucleic acid for cyclooxygenase-2 and production of prostaglandins E and F2alpha in bovine preovulatory follicles are regulated by the progesterone receptor.
TLDR
Results provide strong evidence that periovulatory increases in cyclooxygenase-2 mRNA, PGE, and PGF(2alpha) are mediated by gonadotropin-induced increases in progesterone/PR, indicating that in some species there is an important functional relationship between these pathways in the ovulatory cascade. Expand
Involvement of angiotensin II in the process of gonadotropin-induced ovulation in rabbits.
TLDR
Ang II exerts complex and coordinated control on at least two distinct aspects in the normal ovulatory process, ovulation and oocyte maturation, indicating that hCG-induced PG synthesis is mediated, at least in part, via the activation of AT2 receptors. Expand
The role of angiotensin II in the early stages of bovine ovulation.
TLDR
It is suggested that angiotensin (Ang) II plays a pivotal role in the early mechanism of bovine ovulation via the AT(2) receptor subtype. Expand
Angiotensin II reverses the inhibitory action produced by theca cells on bovine oocyte nuclear maturation.
TLDR
The idea of a role of Ang II in blocking the inhibitory effect of theca cells on nuclear maturation of bovine oocytes is supported, suggesting that it is important during follicular growth and maturation. Expand
Regulation of angiotensin type 2 receptor in bovine granulosa cells.
TLDR
Data suggest that AngII is not associated with follicle atresia in cattle but may have other specific roles during follicle growth. Expand
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