Molecular characterization and phylogenetic analysis of the hemagglutinin 1 protein of human influenza A virus subtype H1N1 circulating in Kenya during 2007-2008.

@article{Bulimo2012MolecularCA,
  title={Molecular characterization and phylogenetic analysis of the hemagglutinin 1 protein of human influenza A virus subtype H1N1 circulating in Kenya during 2007-2008.},
  author={Wallace Bulimo and Rachel A. Achilla and Janet M Majanja and Silvanos O Mukunzi and Meshack O Wadegu and Finnley Osunna and Josephat K Mwangi and James O Njiri and Julia M Wangui and Janet Nyambura and Beryl D Obura and Ken Mitei and Duke Omariba and Shirley Segecha and Martha Nderitu and Alfred Odindo and Charles Adega and Jeremiah Kiponda and Ruth Mupa and Frida Munyazi and George Kissinger and Mohammed Mwakuzimu and Diana Kamola and Elias Muhidin and Daniel Kamau and Steve Kairithia and Margaret Koech and A. Elizabeth Sang and Lynette Onge'ta and David C. Schnabel},
  journal={The Journal of infectious diseases},
  year={2012},
  volume={206 Suppl 1},
  pages={S46-52}
}
BACKGROUND Among influenza viruses, type A viruses exhibit the greatest genetic diversity, infect the widest range of host species, and cause the vast majority of cases of severe disease in humans, including cases during the great pandemics. The hemagglutinin 1 (HA1) domain of the HA protein contains the highest concentration of epitopes and, correspondingly, experiences the most intense positive selection pressure. OBJECTIVES We sought to isolate and genetically characterize influenza A… CONTINUE READING