Molecular characterization and expression of p63 isoforms in human keloids

  title={Molecular characterization and expression of p63 isoforms in human keloids},
  author={Bruna De Felice and Robert Roy Wilson and Massimo Nacca and Loredana F. Ciarmiello and Claudia Pinelli},
  journal={Molecular Genetics and Genomics},
Keloids are benign skin tumors that develop following wounding. A cDNA product from human keloid specimens was identified using the differential display technique. The full-length cDNA was cloned by RT-PCR using human keloid mRNA as template. The predicted product of the cDNA was found to be 99% identical to the ΔN-p63 gamma isotype of p63, a transcription factor that belongs to the family that includes the structurally related tumor suppressor p53 and p73. The ΔN-p63 isotype lacks the acidic N… CONTINUE READING


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