Molecular characterization, metal uptake and copper induced transcriptional activation of efflux determinants in copper resistant isolates of Klebsiella pneumoniae.

@article{Zulfiqar2012MolecularCM,
  title={Molecular characterization, metal uptake and copper induced transcriptional activation of efflux determinants in copper resistant isolates of Klebsiella pneumoniae.},
  author={Soumble Zulfiqar and Abdul Rauf Shakoori},
  journal={Gene},
  year={2012},
  volume={510 1},
  pages={32-8}
}
An efflux system, comprising cus determinants, plays an important role in pumping out this metal in gram negative bacteria exposed to high concentration of copper. Cus determinants comprise two operons, one regulatory (cusRS) and the other structural (cusCFBA). Although the efflux system has been described in quite a few members of Enterobacteriaceae, little is known about this system in Klebsiella spp. We are describing cus determinants in Klebsiella pneumoniae for the first time and also… CONTINUE READING
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