Molecular chaperones throughout the life cycle of the androgen receptor.

@article{Prescott2006MolecularCT,
  title={Molecular chaperones throughout the life cycle of the androgen receptor.},
  author={Jennifer Prescott and Gerhard A. Coetzee},
  journal={Cancer letters},
  year={2006},
  volume={231 1},
  pages={
          12-9
        }
}
Aberrant signaling by the androgen receptor contributes to the initiation and progression of prostate cancer. The involvement of molecular chaperones in the processes of folding, activation, trafficking, and transcriptional activity of the androgen receptor provide different points along the signaling axis where regulation of androgen receptor activity can be hijacked to provide growth signals for clonal selection in cancer progression. Evidence exists of abnormal chaperone expression that… Expand
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References

SHOWING 1-10 OF 57 REFERENCES
Androgen receptor in prostate cancer.
TLDR
AR remains important in the development and progression of prostate cancer and the inhibition of AR activity through mechanisms in addition to androgen ablation, such as modulation of signal transduction pathways, may delay prostate cancer progression. Expand
Mechanism of antiandrogen action: key role of hsp90 in conformational change and transcriptional activity of the androgen receptor.
TLDR
Hsp90 inactivation impedes interaction of androgen-bound GFP-NLS-AR with nuclear components and inhibits transcriptional activity, and it is concluded that hsp90s are required for the acquisition of active conformation in agonist-bound AR to regulate nuclear transfer, nuclear matrix binding, and transcriptionalactivity. Expand
C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation.
TLDR
The finding that Chip overexpression reduced the rate of AR degradation, consistent with an effect on AR folding, was supported by the finding that the effects of exogenous Chip were reproduced by a mutant lacking the U box. Expand
The steroid and thyroid hormone receptor superfamily.
TLDR
A superfamily of regulatory proteins that include receptors for thyroid hormone and the vertebrate morphogen retinoic acid is identified, suggesting mechanisms underlying morphogenesis and homeostasis may be more ubiquitous than previously expected. Expand
Role of molecular chaperones in steroid receptor action.
TLDR
By forming heterocomplexes with hsp90, the chaperone machinery stabilizes the receptor to degradation by the ubiquitin-proteasome pathway of proteolysis and interacts in very dynamic fashion with the liganded, transformed receptor. Expand
Differential in vivo regulation of steroid hormone receptor activation by Cdc37p.
TLDR
In this mutant, hormone-dependent trans activation by androgen receptors was defective at both permissive and restrictive temperatures, although transactivation by glucocorticoid receptors was mildly defective only at the restrictive temperature. Expand
Androgen receptor: A key molecule in the progression of prostate cancer to hormone independence
TLDR
Understanding the changes in AR signaling in the evolution of androgen‐independent prostate cancer will be key to the development of more effective hormone therapy. Expand
Transcriptional activation and nuclear targeting signals of the human androgen receptor.
TLDR
A concerted interplay among the domains of the AR protein in regulating gene transcription is demonstrated, with androgen-dependent nuclear uptake and inhibition of wild type AR by coexpression with an inactive NH2-terminal fragment suggested competition for nuclear factors required for transcriptional regulation. Expand
Functional Interaction of Human Cdc37 with the Androgen Receptor but Not with the Glucocorticoid Receptor*
TLDR
The results show that Cdc37 binds to AR but not to glucocorticoid receptors (GR) synthesized in rabbit reticulocyte lysates, strengthening the notion that CDC37 has a wider range of polypeptide clients than was realized previously. Expand
Disassembly of Transcriptional Regulatory Complexes by Molecular Chaperones
Many biological processes are initiated by cooperative assembly of large multicomponent complexes; however, mechanisms for modulating or terminating the actions of these complexes are not wellExpand
...
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3
4
5
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