Molecular chaperones in protein folding and proteostasis

@article{Hartl2011MolecularCI,
  title={Molecular chaperones in protein folding and proteostasis},
  author={F. U. Hartl and A. Bracher and M. Hayer-Hartl},
  journal={Nature},
  year={2011},
  volume={475},
  pages={324-332}
}
  • F. U. Hartl, A. Bracher, M. Hayer-Hartl
  • Published 2011
  • Biology, Medicine
  • Nature
  • Most proteins must fold into defined three-dimensional structures to gain functional activity. But in the cellular environment, newly synthesized proteins are at great risk of aberrant folding and aggregation, potentially forming toxic species. To avoid these dangers, cells invest in a complex network of molecular chaperones, which use ingenious mechanisms to prevent aggregation and promote efficient folding. Because protein molecules are highly dynamic, constant chaperone surveillance is… CONTINUE READING
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    References

    SHOWING 1-10 OF 113 REFERENCES
    Protein folding in the cytoplasm and the heat shock response.
    • 302
    • PDF
    Adapting Proteostasis for Disease Intervention
    • 1,782
    • PDF
    Converging concepts of protein folding in vitro and in vivo
    • 982
    • PDF
    Molecular chaperones in cellular protein folding
    • 2,685
    Biological and chemical approaches to diseases of proteostasis deficiency.
    • 917
    • PDF
    HSP90 at the hub of protein homeostasis: emerging mechanistic insights
    • 1,384
    • PDF
    Molecular chaperones: assisting assembly in addition to folding.
    • R. J. Ellis
    • Biology, Medicine
    • Trends in biochemical sciences
    • 2006
    • 185
    Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging.
    • 804
    • PDF