Molecular chaperones and neuronal proteostasis.

  title={Molecular chaperones and neuronal proteostasis.},
  author={Heather L. Smith and Wenwen Li and Michael E Cheetham},
  journal={Seminars in cell & developmental biology},
Protein homeostasis (proteostasis) is essential for maintaining the functionality of the proteome. The disruption of proteostasis, due to genetic mutations or an age-related decline, leads to aberrantly folded proteins that typically lose their function. The accumulation of misfolded and aggregated protein is also cytotoxic and has been implicated in the pathogenesis of neurodegenerative diseases. Neurons have developed an intrinsic protein quality control network, of which molecular chaperones… CONTINUE READING
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