Molecular chaperones--cellular machines for protein folding.

  title={Molecular chaperones--cellular machines for protein folding.},
  author={S. H. G. Walter and Johannes Buchner},
  journal={Angewandte Chemie},
  volume={41 7},
Proteins are linear polymers synthesized by ribosomes from activated amino acids. The product of this biosynthetic process is a polypeptide chain, which has to adopt the unique three-dimensional structure required for its function in the cell. In 1972, Christian Anfinsen was awarded the Nobel Prize for Chemistry for showing that this folding process is autonomous in that it does not require any additional factors or input of energy. Based on in vitro experiments with purified proteins, it was… CONTINUE READING