Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant

@inproceedings{Rose2011MolecularCR,
  title={Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant},
  author={Johanna M. Rose and Sergey S. Novoselov and Philip J. Robinson and Michael E Cheetham},
  booktitle={Human molecular genetics},
  year={2011}
}
Mitochondrial dysfunction is characteristic of many neurodegenerative diseases. The Parkinson's disease-associated ubiquitin-protein ligase, Parkin, is important in the elimination of damaged mitochondria by autophagy (mitophagy) in a multistep process. Here, we show that a Parkin RING domain mutant (C289G) fails to redistribute to damaged mitochondria and cannot induce mitophagy after treatment with the mitochondrial uncoupler carbonyl cyanide m-methylhydrazone, because of protein misfolding… CONTINUE READING