Molecular chaperone functions in protein folding and proteostasis.

  title={Molecular chaperone functions in protein folding and proteostasis.},
  author={Yujin E. Kim and Mark S Hipp and Andreas Bracher and Manajit Hayer-Hartl and F. Ulrich Hartl},
  journal={Annual review of biochemistry},
The biological functions of proteins are governed by their three-dimensional fold. Protein folding, maintenance of proteome integrity, and protein homeostasis (proteostasis) critically depend on a complex network of molecular chaperones. Disruption of proteostasis is implicated in aging and the pathogenesis of numerous degenerative diseases. In the cytosol, different classes of molecular chaperones cooperate in evolutionarily conserved folding pathways. Nascent polypeptides interact… CONTINUE READING
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