Molecular chaperone Hsp70 protects neuroblastoma SK-N-SH cells from hypoxic stress

Cellular response to hypoxic stress is based on the activation of the HIF-1 protein factor (hypoxia-inducible factor) composed of two subunits, α and β. HIF-1α is expressed constantly; however, under conditions of normoxia, due to hydroxylation of certain protein sites, its degradation occurs. During hypoxia, hydroxylation is blocked and HIF-1α forms dimers… (More)