Molecular changes in the multistage pathogenesis of head and neck cancer.

  title={Molecular changes in the multistage pathogenesis of head and neck cancer.},
  author={Brian J. Park and Simion I Chiosea and Jennifer R Grandis},
  journal={Cancer biomarkers : section A of Disease markers},
  volume={9 1-6},
Head and neck squamous cell carcinomas (SCCHN) arise in the mucosa of the upper aerodigestive tract at multiple anatomic sites. While tobacco and alcohol exposure remain the primary risk factors for this malignancy, infection with the human papilloma virus is emerging as a major contributing factor to cancers that arise primarily in the oropharynx. Despite therapeutic advances, survival has remained relatively unchanged over the past few decades. Increased understand of the cellular and… CONTINUE READING


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