Molecular biology underlying the clinical heterogeneity of prostate cancer: an update.

@article{Mackinnon2009MolecularBU,
  title={Molecular biology underlying the clinical heterogeneity of prostate cancer: an update.},
  author={Alexander Craig Mackinnon and Benjamin C Yan and Loren J Joseph and Hikmat A. Al-Ahmadie},
  journal={Archives of pathology & laboratory medicine},
  year={2009},
  volume={133 7},
  pages={1033-40}
}
CONTEXT Recent studies have uncovered a number of possible mechanisms by which prostate cancers can become resistant to systemic androgen deprivation, most involving androgen-independent reactivation of the androgen receptor. Genome-wide expression analysis with microarrays has identified a wide array of genes that are differentially expressed in metastatic prostate cancers compared to primary nonrecurrent tumors. Recently, recurrent gene fusions between TMPRSS2 and ETS family genes have been… CONTINUE READING