Molecular biology of sarcomas

  title={Molecular biology of sarcomas},
  author={Jean-Michel Coindre and Alain Aurias},
There are two types of sarcomas with regards to the type of molecular alterations: sarcomas with relatively simple, usually specific lesions and those with complex unspecific lesions. A molecular classification for sarcomas can therefore be proposed (Table 1). Recurrent chromosomal translocations: about 10-15% of all sarcomas bear a recurrent chromosomal translocation (Table 2). The most frequent sarcomas with such an abnormality are dermatofibrosarcoma protuberans (DFSP), myxoid liposarcoma… 

Predicting Malignant Potential of Gastrointestinal Stromal Tumors: Role of p16 and E2F1 Expression

The results suggest that in addition to high Ki-67 proliferation index, high E2F1 expression may also be a useful predictive marker for malignant potential of GISTs.

Osteosarcoma in identical twins: A case report.


This review is meant to provide an introduction to this field and highlight recent findings relative to the molecular biology of musculoskeletal neoplasms and believe that this new information should be included in daily orthopaedic clinical practice since it will undoubtedly change the management of patients with these types of neoplasm.

Tumors of Bone

  • C. Marques
  • Medicine
    Ortner's Identification of Pathological Conditions in Human Skeletal Remains
  • 2019



Molecular pathology of sarcomas.

This review points out the clinical projection of sarcomagenesis elucidation and knowledge of diverse types of molecular alterations in sarcomas, as well as the identification of reliable molecular markers and possible therapeutic targets.

Molecular genetics of sarcomas: Applications to diagnoses and therapy

Evidence from in vitro and in vivo experiments has indicated that the cells of origin of sarcomas are tissue stem cells such as mesenchymal stem cells, and the application of stem cell biology holds the promise of novel treatment options.

Sarcomas: genetics, signalling, and cellular origins. Part 1: The fellowship of TET

The mechanisms whereby specific fusion/mutant gene products participate in sarcoma development and the cellular context that may provide the necessary permissiveness for their expression and oncogenicity are covered.

The role of genetic testing in soft tissue sarcoma

This review focuses on the applicability of genetic testing in the diagnosis and prognosis of soft tissue sarcomas, and gives a realistic appraisal of the ancillary role of molecular techniques, including its advantages and limitations.

Soft tissue sarcomas with complex genomic profiles

The cytogenetic, molecular genetic, and clinicopathologic characteristics of the most common STS displaying complex genomic profiles of spindle cell/pleomorphic unclassified sarcoma are reviewed.

A Rational Approach to Genetic Testing for Sarcoma

  • M. GulleyK. Kaiser-Rogers
  • Biology, Medicine
    Diagnostic molecular pathology : the American journal of surgical pathology, part B
  • 2009
The pathologist's expertize is critical in performing tests that maximize outcome on the basis of the strengths and limitations of each assay in each available specimen type and conveying results to the rest of the healthcare team using proper gene nomenclature and interpreting the findings in a way that facilitates optimal clinical management.

Gastrointestinal Stromal Tumours: An Update

This article reviews chronologically the evolution of the concept of GIST with the gradual application of electron microscopy, immunohistochemistry, DNA ploidy analysis and discusses the impact of these techniques on the pathological assessment and clinical management of Gists.

Fluorescence In Situ Hybridization in the Diagnosis of Soft Tissue Neoplasms: A Review

The molecular alterations (translocations and amplification of gene regions), which have come to define many of these diagnostic entities and the most effective way to evaluate them with FISH with attention to potential pitfalls are reviewed.

Well-differentiated and dedifferentiated liposarcomas

The molecular pathology, general clinical and imaging features, histopathology, new diagnostic tools, and prognosis of ALT-WDLPS and DDLPS are reviewed.

Pathology and genetics of tumours of soft tissue and bone

This list includes tumours of undefined neoplastic nature, which are of uncertain differentiation Bone Tumours, Ewing sarcoma/Primitive neuroedtodermal tumour, Myogenic, lipogenic, neural and epithelial tumours, and others.