Molecular biology of rotaviruses. VIII. Quantitative analysis of regulation of gene expression during virus replication.

@article{Johnson1989MolecularBO,
  title={Molecular biology of rotaviruses. VIII. Quantitative analysis of regulation of gene expression during virus replication.},
  author={Margaret A Johnson and M. A. McCrae},
  journal={Journal of virology},
  year={1989},
  volume={63 5},
  pages={
          2048-55
        }
}
A sensitive and quantitative solution hybridization assay recently developed in this laboratory has been applied to the study of the regulation of viral gene expression in rotavirus-infected cells. Measurement of the cumulative level of viral plus-strand (mRNA) synthesis at hourly intervals throughout the growth cycle has provided evidence for both quantitative and qualitative regulation of transcription. Qualitative control was found only when cycloheximide was used to block protein synthesis… CONTINUE READING

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