Molecular biology of peritoneal carcinomatosis.

  title={Molecular biology of peritoneal carcinomatosis.},
  author={David G. Jayne},
  journal={Cancer treatment and research},
Peritoneal carcinomatosis can be thought of as a sequence of events that together form a peritoneal metastatic cascade. Presently our understanding of the molecular mediators that orchestrate this cascade is ill-understood. Initial tumour-mesothelial interaction appears to involve several adhesion molecules, including CD44, the Selectins, and various leukocyte associated antigens. The exact molecules involved are probably determined by the nature of the metastatic tumour cell. Invasion of the… CONTINUE READING