Molecular biology of anal squamous cell carcinoma: implications for future research and clinical intervention.

@article{Bernardi2015MolecularBO,
  title={Molecular biology of anal squamous cell carcinoma: implications for future research and clinical intervention.},
  author={Maria-Pia Bernardi and Samuel Y.K. Ngan and Michael Michael and Andrew Craig Lynch and Alexander G. Heriot and R G Ramsay and Wayne A Phillips},
  journal={The Lancet. Oncology},
  year={2015},
  volume={16 16},
  pages={e611-21}
}
Anal squamous cell carcinoma is a human papillomavirus-related disease, in which no substantial advances in treatment have been made in over 40 years, especially for those patients who develop disease relapse and for whom no surgical options exist. HPV can evade the immune system and its role in disease progression can be exploited in novel immunotherapy platforms. Although several studies have investigated the expression and inactivation (through loss of heterozygosity) of tumour suppressor… CONTINUE READING
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