Molecular biology of PCSK9: its role in LDL metabolism.

  title={Molecular biology of PCSK9: its role in LDL metabolism.},
  author={Jay D. Horton and Jonathan C. Cohen and Helen H. Hobbs},
  journal={Trends in biochemical sciences},
  volume={32 2},
Proprotein convertase subtilisin-like kexin type 9 (PCSK9) is a newly discovered serine protease that destroys low density lipoprotein (LDL) receptors in liver and thereby controls the level of LDL in plasma. Mutations that increase PCSK9 activity cause hypercholesterolemia and coronary heart disease (CHD); mutations that inactivate PCSK9 have the opposite… CONTINUE READING