Molecular biology of 5-HT receptors

  title={Molecular biology of 5-HT receptors},
  author={J. Hannon and D. Hoyer},
  journal={Behavioural Brain Research},
  • J. Hannon, D. Hoyer
  • Published 2008
  • Biology, Medicine
  • Behavioural Brain Research
  • Serotonin (5-hydroxytryptamine; 5-HT) is a monoamine neurotransmitter whose effects are mediated by at least 13 distinct G protein-coupled receptors (GPCRs) of the type A family which includes the monoamine receptors and a combination of ligand-gated ion channels (5-HT3) of the Cys loop family which constitutes heteropentamers. 5-HT receptors are currently divided into seven classes (5-HT1 to 5-HT7), based on structural, transductional and operational features. While this degree of physical… CONTINUE READING
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