Molecular biology changes associated with LRRK2 mutations in Parkinson's disease.

@article{Lu2008MolecularBC,
  title={Molecular biology changes associated with LRRK2 mutations in Parkinson's disease.},
  author={Y W Lu and Eng-king Tan},
  journal={Journal of neuroscience research},
  year={2008},
  volume={86 9},
  pages={
          1895-901
        }
}
Parkinson's disease (PD) is characterized by progressive dopaminergic neuronal loss in the substantia nigra. The recent discovery of leucine-rich-repeat kinase 2 gene (LRRK2) mutations in PD is significant because these mutations are the most common cause of autosomal dominant PD. Furthermore, a common recurrent mutation (G2019S) is associated with a significant proportion of nonfamilial PD, and a polymorphic variant (G2385R) has been found to increase the risk in the Asian race. The large… CONTINUE READING

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