Molecular biology and neurobiology of choline acetyltransferase

@article{Salvaterra1987MolecularBA,
  title={Molecular biology and neurobiology of choline acetyltransferase},
  author={Paul M. Salvaterra},
  journal={Molecular Neurobiology},
  year={1987},
  volume={1},
  pages={247-280}
}
In the 45 years since the first description of choline acetyltransferase (ChAT;EC 2.3.1.6.), significant progress has been made in characterizing the molecular properties of this important neurotransmitter synthetic enzyme. We are now on the verge of understanding its genetic regulation and biological function(s). TheDrosophila cDNA has been cloned, sequenced, and expressed in both a eucaryotic and a procaryotic system. The levels of ChAT specific mRNA have been determined duringDrosophila… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 171 REFERENCES

Cloning of Drosophila choline acetyltransferase cDNA.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1986
VIEW 3 EXCERPTS

1978a) A fluorometric assay for choline acetyltransferase and its use in the purification of the enzyme from human placenta

L B.Hersh, B. Coe, L. Casey
  • J. Neurochem
  • 1987

An immunocytochernical study of choline acetyltransferasecontaining neurons and axon terminals in normal and partially deafferented hippocampal

D A.Matthews, P M.Salvaterra, G D.Crawford, C R.Houser, J EVaughn
  • 1987

Evolutionary origin of cholinergic macromolecules and thyroglobulin.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1987

Immunohistochemical localization of choline acetyltransferase

E M.Lutz, N M.Tyrer
  • 1987

Molecular properties of the muscarinic acetylcholine receptor

N M.Nathanson
  • Ann. Rev. Neurosci
  • 1987