Molecular biology and immunology for clinicians 17: T-cell signal transduction.

  • L. Sigal
  • Published 2002 in
    Journal of clinical rheumatology : practical…


Peptide antigen recognition by T-cells occurs because of the interaction of the epitope cradled within the peptide-binding groove of the major histocompatibility complex molecule on the surface of an antigen-presenting cell with the T-cell antigen receptor, a heterodimer whose chains belong to the immunoglobulin superfamily. Passage of the message from the… (More)


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