Molecular biology and biochemistry of pyruvate dehydrogenase complexes.

  title={Molecular biology and biochemistry of pyruvate dehydrogenase complexes.},
  author={Mulchand S. Patel and Thomas E. Roche},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={4 14},
In most organisms, the pyruvate dehydrogenase complex catalyzes the pivotal irreversible reaction that leads to the consumption of glucose in the aerobic, energy-generating pathways. A combination of biochemical and molecular biology studies have greatly expanded our understanding of the overall structural organization of this multicomponent system, delineated the locations and elucidated the functions of structural domains of the catalytic components, and revealed significant evolutionary… CONTINUE READING
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