Molecular biology, epidemiology, and pathogenesis of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain.

@article{Ferenczy2012MolecularBE,
  title={Molecular biology, epidemiology, and pathogenesis of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain.},
  author={Michael W. Ferenczy and Leslie J. Marshall and Christian D. S. Nelson and Walter J Atwood and Avindra Nath and Kamel Khalili and Eugene O. Major},
  journal={Clinical microbiology reviews},
  year={2012},
  volume={25 3},
  pages={471-506}
}
Progressive multifocal leukoencephalopathy (PML) is a debilitating and frequently fatal central nervous system (CNS) demyelinating disease caused by JC virus (JCV), for which there is currently no effective treatment. Lytic infection of oligodendrocytes in the brain leads to their eventual destruction and progressive demyelination, resulting in multiple foci of lesions in the white matter of the brain. Before the mid-1980s, PML was a relatively rare disease, reported to occur primarily in those… CONTINUE READING
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