[Molecular-biologic aspects of interaction between nervous and immune systems].


The problem of the neuro-immuno interactions on the level of the protein trans-factors, stimulating interleukin-2 (IL-2) gene expression was discussed. The physico-chemical and functional parameters of the low molecular nuclear proteins (SP and BP- 14, 18, 19 kDs) isolated from splenic and brain cells of immunized rats were studied. The binding of these proteins to the regulatory region of IL-2 gene in vitro and stimulation of the IL-2mRNA synthesis in splenic T-lymphocytes culture in normal conditions were shown. The protective effect of SP and BP on the IL-2mRNA synthesis in stressful conditions and by the T-cells treatment with the CsA was demonstrated.

Cite this paper

@article{Korneva1997MolecularbiologicAO, title={[Molecular-biologic aspects of interaction between nervous and immune systems].}, author={Elena A. Korneva and O. I. Golovko and T. V. Kazakova}, journal={Voprosy medit︠s︡inskoĭ khimii}, year={1997}, volume={43 5}, pages={321-9} }