Molecular behavior adapts to context: heparanase functions as an extracellular matrix-degrading enzyme or as a T cell adhesion molecule, depending on the local pH

@article{Gilat1995MolecularBA,
  title={Molecular behavior adapts to context: heparanase functions as an extracellular matrix-degrading enzyme or as a T cell adhesion molecule, depending on the local pH},
  author={David Gilat and Rami Hershkoviz and I Goldkorn and Liora Cahalon and Gil Korner and Israel Vlodavsky and Ofer Lider},
  journal={The Journal of Experimental Medicine},
  year={1995},
  volume={181},
  pages={1929 - 1934}
}
Migration of lymphocytes into inflammatory sites requires their adhesion to the vascular endothelium and subendothelial extracellular matrix (ECM). The ensuing penetration of the ECM is associated with the expression of ECM-degrading enzymes, such as endo-beta-D glucuronidase (heparanase), which cleaves heparan sulfate (HS) proteoglycans. We now report that, depending on the local pH, a mammalian heparanase can function either as an enzyme or as an adhesion molecule. At relatively acidified pH… CONTINUE READING