Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases

@article{Redondo2008MolecularBO,
  title={Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases},
  author={P. Redondo and J. Prieto and I. Mu{\~n}oz and Andreu Alib{\'e}s and F. Stricher and Luis Serrano and J. Cabaniols and F. Daboussi and S. Arnould and Christophe Perez and P. Duchateau and F. P{\^a}ques and F. Blanco and G. Montoya},
  journal={Nature},
  year={2008},
  volume={456},
  pages={107-111}
}
Xeroderma pigmentosum is a monogenic disease characterized by hypersensitivity to ultraviolet light. The cells of xeroderma pigmentosum patients are defective in nucleotide excision repair, limiting their capacity to eliminate ultraviolet-induced DNA damage, and resulting in a strong predisposition to develop skin cancers. The use of rare cutting DNA endonucleases—such as homing endonucleases, also known as meganucleases—constitutes one possible strategy for repairing DNA lesions. Homing… Expand
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