Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases

@article{Redondo2008MolecularBO,
  title={Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases},
  author={Pilar Redondo and Jes{\'u}s Prieto and In{\'e}s G. Mu{\~n}oz and Andreu Alib{\'e}s and François Stricher and Luis Serrano and J P Cabaniols and Fayza Daboussi and Sylvain Arnould and Christophe Perez and Philippe Duchateau and Fr{\'e}d{\'e}ric P{\^a}ques and Francisco J. Blanco and Guillermo Montoya},
  journal={Nature},
  year={2008},
  volume={456},
  pages={107-111}
}
Xeroderma pigmentosum is a monogenic disease characterized by hypersensitivity to ultraviolet light. The cells of xeroderma pigmentosum patients are defective in nucleotide excision repair, limiting their capacity to eliminate ultraviolet-induced DNA damage, and resulting in a strong predisposition to develop skin cancers. The use of rare cutting DNA endonucleases—such as homing endonucleases, also known as meganucleases—constitutes one possible strategy for repairing DNA lesions. Homing… 

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