Molecular basis of transcriptional mutagenesis at 8-oxoguanine.

  title={Molecular basis of transcriptional mutagenesis at 8-oxoguanine.},
  author={Gerke E. Damsma and Patrick Cramer},
  journal={The Journal of biological chemistry},
  volume={284 46},
Structure-function analysis has revealed the mechanism of yeast RNA polymerase II transcription at 8-oxoguanine (8-oxoG), the major DNA lesion resulting from oxidative stress. When polymerase II encounters 8-oxoG in the DNA template strand, it can misincorporate adenine, which forms a Hoogsteen bp with 8-oxoG at the active center. This requires rotation of… CONTINUE READING