Molecular basis of the cell specificity of cytokine action.

  title={Molecular basis of the cell specificity of cytokine action.},
  author={Katsuhiko Ishihara and Toshio Hirano},
  journal={Biochimica et biophysica acta},
  volume={1592 3},
The molecular cloning and biological analyses of cytokines have led us to a general understanding of their pleiotropism and redundancy. These features have been ascribed to the composition of cytokine receptor complexes, which include a signal-transducing receptor subunit that is used by all members of a cytokine family and a binding subunit that is specific for each cytokine. Even though a given cytokine uses the same receptor complex when binding to various cell types, the cytokine elicits… CONTINUE READING