Molecular basis of the adult i phenotype and the gene responsible for the expression of the human blood group I antigen.

@article{Yu2001MolecularBO,
  title={Molecular basis of the adult i phenotype and the gene responsible for the expression of the human blood group I antigen.},
  author={Lung-Chih Yu and Yuh-Ching Twu and Cherry Ying-Yi Chang and Min Lin},
  journal={Blood},
  year={2001},
  volume={98 13},
  pages={
          3840-5
        }
}
The human blood group i and I antigens are characterized as linear and branched repeats of N-acetyllactosamine, respectively. Conversion of the i to the I structure requires the activity of I-branching beta-1,6-N-acetylglucosaminyltransferase (IGnT). Thus the blood group I gene is assigned to encode a beta-1,6-N-acetylglucosaminyltransferase; however, its identity has not been confirmed. The null phenotype of I, the adult i phenotype, provides a means to identify the I gene. Interestingly, the… CONTINUE READING

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