Molecular basis of the CRAC channel.

  title={Molecular basis of the CRAC channel.},
  author={Michael D Cahalan and Shenyuan L. Zhang and Andriy V. Yeromin and Kari L. Ohlsen and Jack Roos and Kenneth A. Stauderman},
  journal={Cell calcium},
  volume={42 2},
Ca(2+) release-activated Ca(2+) (CRAC) channels, located in the plasma membrane, are opened upon release of Ca(2+) from intracellular stores, permitting Ca(2+) entry and sustained [Ca(2+)](i) signaling that replenishes the store in numerous cell types. This mechanism is particularly important in T lymphocytes of the immune system, providing the missing link in the signal transduction cascade that is initiated by T cell receptor engagement and leads to altered expression of genes that results… CONTINUE READING


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