Molecular basis of sodium butyrate-dependent proapoptotic activity in cancer cells.

  title={Molecular basis of sodium butyrate-dependent proapoptotic activity in cancer cells.},
  author={Beata Pająk and Arkadiusz Orzechowski and Barbara Gajkowska},
  journal={Advances in medical sciences},
This review outlines the molecular events that accompany the antitumor action of sodium butyrate (NaBt). Butyrate, a low-molecular weight four-carbon chain volatile fatty acid (VFA) has been previously shown to withdraw cells from cell cycle or to promote cell differentiation, and finally to induce programmed cell death. Recent advances in molecular biology indicate, that this product of large bowel microbial fermentation of dietary fiber, might evoke the above-mentioned effects by indirect… CONTINUE READING
28 Citations
52 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 28 extracted citations


Publications referenced by this paper.
Showing 1-10 of 52 references

histone deacetylase inhibitors modulate the sensitivity of tumor necrosis factor-related apoptosis-inducing ligand-resistant bladder tumor cells

  • JK earel, Vanoosten Ri, TS Griffith
  • Cancer Res,
  • 2006
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…