Molecular basis of selective atrial fibrosis due to overexpression of transforming growth factor-β1.

@article{Rahmutula2013MolecularBO,
  title={Molecular basis of selective atrial fibrosis due to overexpression of transforming growth factor-β1.},
  author={Dolkun Rahmutula and Gregory M. Marcus and Emily E. Wilson and Chun-hua Ding and Yuanyuan Xiao and Agnes C. Paquet and Rebecca Barbeau and Andrea J Barczak and David J. Erle and Jeffrey E. Olgin},
  journal={Cardiovascular research},
  year={2013},
  volume={99 4},
  pages={769-79}
}
AIMS Animal studies show that transforming growth factor-β1 (TGF-β1) is an important mediator of atrial fibrosis and atrial fibrillation (AF). This study investigated the role of TGF-β1 in human AF and the mechanism of atrial-selective fibrosis. METHODS AND RESULTS Atrial specimens from 17 open heart surgery patients and left atrial and ventricular specimens from 17 explanted hearts were collected to assess the relationship between TGF-β1, AF, and differential atrial vs. ventricular TGF-β1… CONTINUE READING

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