Molecular basis of rifampin and isoniazid resistance in Mycobacterium bovis strains isolated in Sardinia, Italy.

@article{Sechi2001MolecularBO,
  title={Molecular basis of rifampin and isoniazid resistance in Mycobacterium bovis strains isolated in Sardinia, Italy.},
  author={Leonardo A. Sechi and Stefania Zanetti and Maurizio Sanguinetti and Paola Molicotti and Lucio Romano and Guido Sisinnio Leori and Giovanni Delogu and Stefania Boccia and Marilena La Sorda and Giovanni Fadda},
  journal={Antimicrobial agents and chemotherapy},
  year={2001},
  volume={45 6},
  pages={1645-8}
}
Fourteen of 22 (68%) Mycobacterium bovis strains isolated from cattle in Sardinia were found to be resistant to rifampin and isoniazid. Analysis of the rpoB and the katG, oxyR-ahpC, and inhA gene regions of these strains was performed in order to investigate the molecular basis of rifampin and isoniazid resistance, respectively. The most frequent mutation, encountered in 6 of 10 strains (60%), was in the rpoB gene; it occurred, at codon position 521 and resulted in leucine changed to proline… CONTINUE READING
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