Molecular basis of regulatory variation at coronary heart disease associated loci

@article{Miller2015MolecularBO,
  title={Molecular basis of regulatory variation at coronary heart disease associated loci},
  author={Clint L. Miller and M. Pjanic and T. Assimes and S. Montgomery and W. Greenleaf and Thomas Quertermous},
  journal={Atherosclerosis},
  year={2015},
  volume={241}
}
  • Clint L. Miller, M. Pjanic, +3 authors Thomas Quertermous
  • Published 2015
  • Biology, Medicine
  • Atherosclerosis
  • Genome-wide association studies have identified 46 replicated genetic loci for coronary heart disease (CHD), and 104 loci associated at a 5% false discovery rate. However, the regulatory mechanisms of these associations largely remain elusive. Given that the majority of these CHD-associated loci reside in non-coding regions, they are predicted to function via context-specific gene regulation. Recent high-throughput assays of regulatory function include the assay for transposase-accessible… CONTINUE READING