Molecular basis of prion diseases.

  title={Molecular basis of prion diseases.},
  author={Detlev Riesner},
  journal={Journal of neurovirology},
  volume={8 Suppl 2},
Fatal neurodegenerative diseases have been known for more than 300 years. As early as 1759, the scrapie disease of sheep was mentioned as a lethal and transmissible disease in a german veterinary textbook by Leopoldt (1759). Experimental transmission was shown in 1936 by Cuillé (1938). Not knowing about the similarity to the sheep disease, the neurologists Alfons Jakob (1921) and Hans Creutzfeldt (1920) described cases of a progressive neurodegeneration of human patients between 1920 and 1922… CONTINUE READING


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