Molecular basis of osmotic regulation.

@article{Burg1995MolecularBO,
  title={Molecular basis of osmotic regulation.},
  author={Maurice B. Burg},
  journal={The American journal of physiology},
  year={1995},
  volume={268 6 Pt 2},
  pages={F983-96}
}
Cells almost universally respond to the stress of long-term hyperosmolality by accumulating compatible organic osmolytes. This allows them to maintain normal cell volume without a deleterious increase in intracellular inorganic ion concentration. Cells in the renal inner medulla are exposed to variable concentrations of salt and urea that may reach molal levels. The organic osmolytes that they accumulate include sorbitol, betaine, inositol, taurine, and glycerophosphocholine (GPC). This review… CONTINUE READING
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