Molecular basis of oligoubiquitin-dependent internalization of membrane proteins in Mammalian cells.

@article{Barrire2006MolecularBO,
  title={Molecular basis of oligoubiquitin-dependent internalization of membrane proteins in Mammalian cells.},
  author={H. de la Barri{\`e}re and Csilla Nemes and Delphine Lechardeur and Mina Khan-Mohammad and Klaus J. Fruh and Gergely L Lukacs},
  journal={Traffic},
  year={2006},
  volume={7 3},
  pages={
          282-97
        }
}
Ubiquitination induced down-regulation of cell surface proteins by internalization and lysosomal targeting plays a fundamental role in cell physiology and pathogenesis of diseases. The molecular basis of a single ubiquitin (Ub) as an autonomous endocytic signal, the widely accepted mechanism, however, remains elusive in higher eukaryotes. Using Ub containing reporter proteins without signalling abilities, we present evidence that only multiple Ub moieties, linked either covalently or assembled… CONTINUE READING
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