Molecular basis of mechanosensory transduction

@article{Gillespie2001MolecularBO,
  title={Molecular basis of mechanosensory transduction},
  author={Peter G. Gillespie and Richard G Walker},
  journal={Nature},
  year={2001},
  volume={413},
  pages={194-202}
}
Mechanotransduction — a cell's conversion of a mechanical stimulus into an electrical signal — reveals vital features of an organism's environment. From hair cells and skin mechanoreceptors in vertebrates, to bristle receptors in flies and touch receptors in worms, mechanically sensitive cells are essential in the life of an organism. The scarcity of these cells and the uniqueness of their transduction mechanisms have conspired to slow molecular characterization of the ensembles that carry out… 
Mechanosensitive ion channels: molecules of mechanotransduction
  • B. Martinac
  • Biology, Medicine
    Journal of Cell Science
  • 2004
TLDR
There has been major progress in research on microbial MS channels, and cloning and sequencing of MS channels from several species has provided insights into their evolution, their physiological functions in prokaryotes and eukaryotes, and their potential roles in the pathology of disease.
Drosophila Mechanosensory Transduction
TLDR
Drosophila mechanosensory neurons were put forward as cellular paradigms for mechanotransduction and mechanogated ion channel function in the context of proprio- and nociception as well as the detection of substrate vibrations, touch, gravity, and sound.
Drosophila Mechanotransduction—Linking Proteins and Functions
TLDR
This work describes how the mechanics of the Drosophila ear can be used to evaluate the roles of identified proteins in the process of mechanosensation and, specifically, their contributions to mechanotransduction.
Cadherins and mechanotransduction by hair cells.
  • U. Müller
  • Biology, Medicine
    Current opinion in cell biology
  • 2008
TLDR
These studies show that cadherin 23 (CDH23) and protocadherin 15 (PCDH15) form several of the extracellular filaments that connect the stereocilia and kinocilium of a hair cell into a bundle.
Studies of mechanosensation using the fly.
  • A. Jarman
  • Medicine, Biology
    Human molecular genetics
  • 2002
TLDR
For human geneticists, it is expected that Drosophila studies will provide a source of candidate genes whose human homologues can be examined for roles in mechanosensory development, function and disease.
Cell membrane mechanics and mechanosensory transduction.
TLDR
The current knowledge about cell mechanics and the role cell mechanics plays for the function of mechanosensitive ion channels as a special class of mechanoreceptors functioning as molecular transducers of mechanical stimuli on a millisecond timescale are reviewed.
Drosophila Mechanotransduction Channels
In Chap. 4, we discussed the working mechanisms of several fly mechanoreceptors. These mechanoreceptors have developed striking structural-mechanical features that couple the environmental signals to
Overview of Mechanosensory Transduction
TLDR
This chapter provides a definition on “what is mechanosensory transduction” at the cell biological level and listing the fundamental questions in this emerging field and focuses on how mechanotransduction contributes to the functions of these cells and the molecular basis of the mechanosensing transduction in each model cell.
The Mechanotransduction Machinery of Hair Cells
TLDR
Components of the mechanotransduction machinery in hair cells have been identified and several are encoded by genes linked to deafness in humans, which indicates that defects in the mechanosynthesis machinery are the underlying cause of some forms of hearing impairment.
Mechanosensitive Cation Currents and their Molecular Counterparts in Mammalian Sensory Neurons
TLDR
A review of the methodological approaches and properties of mechanically gated ion channels in mammalian somatosensory neurons summarizes the basic mechanisms by which the senses of touch and pain are transduced in mammals.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 112 REFERENCES
A Drosophila mechanosensory transduction channel.
TLDR
This data indicates that the no mechanoreceptor potential C (nompC) gene encodes a new ion channel that is essential for mechanosensory transduction, and D. melanogaster NOMPC and a Caenorhabditis elegans homolog were selectively expressed in mechanos Sensory organs.
Interaction Between a Putative Mechanosensory Membrane Channel and a Collagen
TLDR
Genetic evidence was obtained that the unc-105 gene product represents a degenerin homolog affecting C. elegans muscles and that this putative channel interacts with type IV collagen in the extracellular matrix underlying the muscle cell, which may serve as a mechanism of stretch-activated muscle contraction.
Developmental Genetics of the Mechanosensory Neurons of Caenorhabditis elegans
Touch sensitivity in the nematode Caenwhabditis elegans is mediated by a set of six sensory neurons, the microtubule cells, of well-characterized anatomy and connectivity. The normal touch response
Molecular modeling of mechanotransduction in the nematode Caenorhabditis elegans.
Genetic and molecular studies of touch avoidance in the nematode Caenorhabditis elegans have resulted in a molecular model for a mechanotransducing complex. mec-4 and mec-10 encode proteins
A molecular model for mechanosensation in Caenorhabditis elegans.
  • M. Chalfie
  • Biology, Medicine
    The Biological bulletin
  • 1997
TLDR
Analyzing the genes needed for mechanosensation in the nematode Caenorhabditis elegans hopes to gain a molecular understanding of the molecules needed for mechanical signaling, which underlies the senses of touch, hearing, and balance.
Genetically Similar Transduction Mechanisms for Touch and Hearing in Drosophila
TLDR
Recording sound-evoked potentials originating from ciliated sensory neurons in Johnston's organ suggests that in addition to the shared transduction mechanism, axonemal integrity and possibly ciliary motility are required for signal amplification or transduction by chordotonal sensory neurons.
Calmodulin controls adaptation of mechanoelectrical transduction by hair cells of the bullfrog's sacculus.
  • R. G. Walker, A. Hudspeth
  • Medicine, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1996
TLDR
Evidence indicates that calmodulin binds to and controls the activity of hair-bundle myosin I, the putative adaptation motor of Ca2+-dependent adaptation.
A Molecular Component of the Arterial Baroreceptor Mechanotransducer
TLDR
The finding of the gamma subunit of ENaC localized to the site of mechanotransduction in baroreceptor nerve terminals innervating the aortic arch and carotid sinus suggests that ENac subunits may be components of the barorecept mechanotranducer and pave the way to a better definition of mechanisms responsible for blood pressure regulation and hypertension.
Mechano-electrical transduction in mice lacking the alpha-subunit of the epithelial sodium channel.
TLDR
The results suggest that the vertebrate mechano-electrical transducer apparatus does not include the alpha-subunit of the epithelial Na+ channel, ENaC, a candidate gene for this function.
Mechanical relaxation of the hair bundle mediates adaptation in mechanoelectrical transduction by the bullfrog's saccular hair cell.
  • J. Howard, A. Hudspeth
  • Chemistry, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1987
Mechanoelectrical transduction by hair cells of the frog's internal ear displays adaptation: the electrical response to a maintained deflection of the hair bundle declines over a period of tens of
...
1
2
3
4
5
...