Molecular basis of maillard amide-advanced glycation end product (AGE) formation in vivo.

@article{Henning2011MolecularBO,
  title={Molecular basis of maillard amide-advanced glycation end product (AGE) formation in vivo.},
  author={Christian Henning and Mareen Smuda and Matthias Girndt and Christof Ulrich and Marcus A Glomb},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 52},
  pages={44350-6}
}
The Maillard reaction in vivo entails alteration of proteins or free amino acids by non-enzymatic glycation or glycoxidation. The resulting modifications are called advanced glycation end products (AGEs) and play a prominent role in various pathologies, including normoglycemic uremia. Recently, we established a new class of lysine amide modifications in vitro. Now, human plasma levels of the novel amide-AGEs N(6)-acetyl lysine, N(6)-formyl lysine, N(6)-lactoyl lysine, and N(6)-glycerinyl lysine… CONTINUE READING

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