Molecular basis of lithium action: integration of lithium-responsive signaling and gene expression networks

@article{Lenox2003MolecularBO,
  title={Molecular basis of lithium action: integration of lithium-responsive signaling and gene expression networks},
  author={Robert H. Lenox and Le Wang},
  journal={Molecular Psychiatry},
  year={2003},
  volume={8},
  pages={135-144}
}
The clinical efficacy of lithium in the prophylaxis of recurrent affective episodes in bipolar disorder is characterized by a lag in onset and remains for weeks to months after discontinuation. Thus, the long-term therapeutic effect of lithium likely requires reprogramming of gene expression. Protein kinase C and glycogen synthase kinase-3 signal transduction pathways are perturbed by chronic lithium at therapeutically relevant concentrations and have been implicated in modulating synaptic… CONTINUE READING

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