Molecular basis of intrinsic macrolide resistance in the Mycobacterium tuberculosis complex.

@article{Burinkov2004MolecularBO,
  title={Molecular basis of intrinsic macrolide resistance in the Mycobacterium tuberculosis complex.},
  author={Karol{\'i}na Buri{\'a}nkov{\'a} and F. Doucet-populaire and Olivier Dorson and Anne Gondran and Jean-Claude Ghnassia and Jaroslav Weiser and Jean-Luc Pernodet},
  journal={Antimicrobial agents and chemotherapy},
  year={2004},
  volume={48 1},
  pages={
          143-50
        }
}
The intrinsic resistance of the Mycobacterium tuberculosis complex (MTC) to most antibiotics, including macrolides, is generally attributed to the low permeability of the mycobacterial cell wall. However, nontuberculous mycobacteria (NTM) are much more sensitive to macrolides than members of the MTC. A search for macrolide resistance determinants within the genome of M. tuberculosis revealed the presence of a sequence encoding a putative rRNA methyltransferase. The deduced protein is similar to… CONTINUE READING

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