Molecular basis of interferon resistance in hepatitis C virus.


Resistance to interferon (IFN) in hepatitis C virus (HCV) differs from resistance to standard, directly-acting antiviral (DAA) agents in that the virus confronts a multicomponent antiviral state evoked by IFN. This renders unlikely the repeated selection of the same specific mutations that confer an IFN-resistance phenotype. Comparison of amino acid… (More)
DOI: 10.1016/j.coviro.2014.05.003


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