Molecular basis of intercellular adhesion in the biofilm-forming Staphylococcus epidermidis.

  title={Molecular basis of intercellular adhesion in the biofilm-forming Staphylococcus epidermidis.},
  author={Christine Heilmann and Oliver Schweitzer and Christine Gerke and Nongnuch Vanittanakom and Dietrich Mack and Friedrich G{\"o}tz},
  journal={Molecular microbiology},
  volume={20 5},
The Staphylococcus epidermidis genes icaABC are involved in the synthesis of the polysaccharide intercellular adhesin (PIA), which is located mainly on the cell surface, as shown by immunofluorescence studies with PIA-specific antiserum. PIA was shown to be a linear beta-1,6-linked glucosaminoglycan composed of at least 130 2-deoxy-2-amino-D-glucopyranosyl residues of which 80-85% are N-acetylated, the rest being non-N-acetylated and positively charged. A transposon insertion in the icaABC gene… CONTINUE READING
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