Molecular basis of imprinting disorders affecting chromosome 14: lessons from murine models.

@article{Howard2015MolecularBO,
  title={Molecular basis of imprinting disorders affecting chromosome 14: lessons from murine models.},
  author={Mark Howard and Marika Charalambous},
  journal={Reproduction},
  year={2015},
  volume={149 5},
  pages={
          R237-49
        }
}
Uniparental inheritance of chromosome 14q32 causes developmental failure during gestation and early postnatal development due to mis-expression of a cluster of imprinted genes under common epigenetic control. Two syndromes associated with chromosome 14q32 abnormalities have been described, Kagami-Ogata and Temple syndromes. Both of these syndromes are characterised by specific impairments of intrauterine development, placentation and early postnatal survival. Such abnormalities arise because… CONTINUE READING

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