Molecular basis of human von Willebrand disease: analysis of platelet von Willebrand factor mRNA.

Abstract

von Willebrand disease (vWD), the most common inherited bleeding disorder in humans, can result from either a quantitative or a qualitative defect in the adhesive glycoprotein, von Willebrand factor (vWF). Molecular studies of vWD have been limited by the large size of the vWF gene and difficulty in obtaining the vWF mRNA from patients. By use of an… (More)

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Cite this paper

@article{Ginsburg1989MolecularBO, title={Molecular basis of human von Willebrand disease: analysis of platelet von Willebrand factor mRNA.}, author={David Ginsburg and Barbara A. Konkle and Jas Gill and Robert R. Montgomery and Paula L Bockenstedt and T. A. Johnson and A. Y. Yang}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1989}, volume={86 10}, pages={3723-7} }