Molecular basis of histone H3K4me3 recognition by ING4.

@article{Palacios2008MolecularBO,
  title={Molecular basis of histone H3K4me3 recognition by ING4.},
  author={Alicia Palacios and In{\'e}s G. Mu{\~n}oz and David Pantoja-Uceda and Maria Jose Marcaida and Daniel T Torres and Jose M Martin-Garcia and Irene Luque and Guillermo Montoya and Francisco J Blanco},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 23},
  pages={15956-64}
}
The inhibitors of growth (ING) family of tumor suppressors consists of five homologous proteins involved in chromatin remodeling. They form part of different acetylation and deacetylation complexes and are thought to direct them to specific regions of the chromatin, through the recognition of H3K4me3 (trimethylated K4 in the histone 3 tail) by their conserved plant homeodomain (PHD). We have determined the crystal structure of ING4-PHD bound to H3K4me3, which reveals a tight complex stabilized… CONTINUE READING
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