Molecular basis of glucocorticoid-resistant syndromes.

  title={Molecular basis of glucocorticoid-resistant syndromes.},
  author={Suzanne Werner and Mikael Br{\"o}nneg{\aa}rd},
  volume={61 4},
Generalized inherited glucocorticoid resistance (GIGR) is a rare syndrome characterized by elevated levels of plasma cortisol but lacking the symptoms of Cushing's syndrome. Biochemically, the condition is characterized by a relative resistance to glucocorticoids that can be compensated for by the elevated levels of cortisol. The inheritance pattern of GIGR is incompletely understood, and one of the central questions is whether there is a correlation between genotype and phenotype. Analysis of… CONTINUE READING

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